Tuesday, May 28, 2013

Asbestos Mesothelioma ; Gendicine- Is Mesothelioma Curable

Europe and the United States are probably still a year away from licensing gene therapy, however, there's currently at least clinical trials testing gene therapy for mesothelioma. They include the University of Pennsylvania and the Louisiana State University. Regrettably, gene therapy research took a massive blow in 1999 when teenager Jesse Gelsinger died in the coursework of a gene therapy clinical trial at the University of Pennsylvania.

Despite that, China is now the only country in the world that has already approved gene therapy- is  Mesothelioma Curable

 On October 16, 2003, the drug named Gendicine was approved by the State Food and Drug Administration of China. Gendicine had over five years of clinical trials before it was approved. They have currently used this therapy on over 4500 patients and have followed their patient's progress for over 6 years. Now, hundreds of cancer patients from around the globe are travelling to Beijing to receive this leading edge treatment.

Since there's no other approved gene therapy treatments in the world, lots of desperate cancer patients from North America and Europe are travelling to Beijing, China to receive treatment of Gendicine.

The clinical trials of Gendicine included 135 patients and results showed that 64% of patients showed tumour regression after 8 every week injections in combination with radiation therapy. According to the clinical trial results, using Gendicine with chemotherapy and radiation therapy can improve the efficacy by thrice. The only side effect of Gendicine is a typical overnight fever.

After cycles of treatments, over months, a pet scan showed that they was cancer free- is  Mesothelioma Curable
 The controversy around this story is that although Richard's cancer was gone there's some doubts as to whether the chemotherapy or Gendicine cured it. Dr. Mark Persky, a cancer specialist remarked that "According to my review, there is no way of telling whether or the other caused tumour regression".

Richard Weissenborn from Los angeles, USA, had tongue cancer that had spread to his lymph nodes and was given months to live in July of 2006. They was treated with Gendicine and chemotherapy by Dr. Li Dinggang at the Haidan Hospital in Beijing at a cost of about $30,000 U.S.

In a healthy cell, there is a gene called the p53 gene, which can repair DNA, arrest cell growth, and initiate a cellular self destruction if the cell destroy is great as in the case of cancer. However, in a study by the Chinese Academy of Preventive Medicine in Beijing, they found that there was a high occurrence of p53 gene destroy in asbestos related cancers such as mesothelioma.

Gendicine works by reactivating the p53 gene, which acts as tumour suppressant but is shut off in a cancer cell because it may become deactivated by mutagens such as asbestos, chemicals and radiation. Gendicine treatment makes use of a virus as a medium to carryover the p53 gene in to the cancerous cells and causes the p53 gene to reactive and initiate self destruction (apoptosis) of the cancer cell.

Paul Folkmann is a mesothelioma cancer researcher- is  Mesothelioma Curable
 To learn more about gendicine, visit: New Mesothelioma Treatment. There you will also find information on mesothelioma treatments, tales of hope, and the latest news.
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